Metabolaid and its effects: The role of AMPK in the body

Imagine that your body is like an intelligent engine that needs constant energy to run. When the energy runs out, someone has to come and turn on the ultimate energy saver and restart the internal processes. This is how AMPK – adenosine monophosphate-activated protein kinase – works in the body. AMPK – adenozín monofosfát-aktivovaná proteínkináza..

AMPK is an enzyme that plays a key role in regulating energy balance. When cells detect that they are lacking energy, AMPK is activated and helps kick-start the processes to obtain it. It's like an internal "general" that decides where the energy goes and what stops.

How does AMPK work?

AMPK (adenosine monophosphate-activated protein kinase) is the main regulator of energy metabolism in cells. It acts as an "energy sensor" that monitors ATP levels (the main source of cellular energy) and, when energy reserves decline, activates processes that increase energy production and reduce energy consumption.

When energy levels in cells drop (for example, after intense exercise, fasting, or stress), AMP levels rise and ATP, our main "fuel," drops. AMPK picks up this signal and immediately triggers processes that help:

• get more energy (by burning fat and glucose)
• and, conversely, stop processes that consume energy unnecessarily (e.g., fat formation).

Main functions of AMPK in the body

1. Promotes fat burning (lipolysis) and reduces fat storage

Activates enzymes that promote the oxidation of fatty acids – the burning of fat for energy.

Inhibits fat synthesis (lipogenesis), preventing excessive fat storage in the body and liver.

➡ Significance for weight loss and metabolic health: When AMPK is active, the body uses fat more efficiently as fuel, which can help reduce body fat and prevent obesity.

2. Improves insulin sensitivity and regulates blood sugar levels

AMPK increases glucose uptake into muscle cells by activating GLUT4 transporters even without insulin.

Suppresses glucose production in the liver (gluconeogenesis), thereby stabilizing blood sugar levels.

➡ Significance for diabetes: Activation of AMPK may help prevent insulin resistance and type 2 diabetes.

3. Stimulates mitochondrial biogenesis (production of new mitochondria)

Activates the PGC-1α gene, which promotes the formation of new mitochondria and increases the energy efficiency of cells.

➡ Significance for energy and longevity: More mitochondria means better energy utilization and better resistance to aging.

4. Supports autophagy – natural detoxification and cell regeneration

AMPK activates the processes of autophagy – "cleaning" in cells. This means that the body removes damaged parts of cells and recycles them into new ones, which can help slow down aging and improve regeneration.

➡ Significance for longevity and protection against neurodegeneration: Autophagy can help prevent aging and neurodegenerative diseases such as Alzheimer's disease.

5. Suppresses inflammatory processes

AMPK inhibits inflammatory pathways (e.g., NF-κB) that are associated with chronic inflammation, obesity, and insulin resistance.

➡ Importance for health: Reducing chronic inflammation can help prevent metabolic diseases and cardiovascular problems.

How can we naturally activate AMPK?

Fasting and calorie restriction – Low energy status (low ATP, high AMP) activates AMPK.

Exercise – Endurance activities such as running or interval training increase AMPK.

Polyphenols and natural activators – Certain substances can support AMPK:

• Curcumin (turmeric)
• Berberine (a natural supplement that has a similar effect to metformin)
• Extract of Hibiscus sabdariffa and Lippia citriodora in SKEENEFFECT Metabolic Health
• Resveratrol (red grapes)
• Quercetin (onions, apples) Natural Metabolic Health Natural Metabolic Health

Low-carbohydrate diet – Less sugar in the diet can promote AMPK activation and improve fat metabolism

Summary – why is AMPK important?

✅Regulates fat burning and prevents fat storage

✅ Lowers blood sugar levels and improves insulin sensitivity

✅ Promotes mitochondrial biogenesis and increases energy efficiency

✅ Triggers autophagy and cell detoxification

✅ Reduces inflammation and may prolong longevity

✅ AMPK activation may be key to healthy metabolism, weight loss, and longevity.

AMPK is like the switch for our internal energy – it cleverly distributes it, conserves it, and also helps it regenerate. Supporting AMPK through exercise, fasting, and a healthy diet may be the key to better health and a longer life.

If you want to support your health today, AMPK is the right place to start! Discover the power of AMPK with Metabolaid: Natural Metabolic Health.